Galveston Capital Tourism And Marketing: Potential Zika Vaccine Protects Against Infection, Pregnancy Transmission & Testicular Damage

For the first time, a collaborative team led by The University of Texas Medical Branch at Galveston has shown that a potential Zika vaccine quickly can protect fetuses against infection as well as protect males against testicular infection and injury. It also prevents a lowered sperm count after one vaccination. The findings are currently available in Nature Communications.

Although Zika infection typically results in mild or symptom-free infections in healthy individuals, infected pregnant women without symptoms may still give birth to a baby with birth defects like microcephaly. Similarly, infected men without noticeable signs of illness may still incur testicular injury and lowered sperm count. The Zika virus could infect the male reproductive system for several months, posing risk for sexual transmission.

“This study showed, for the first time, that a single-dose vaccine candidate could prevent Zika infection in non-human primates, block mother-to-fetus transmission, and stop male testis infection in mice,” said UTMB’s Pei-Yong Shi, senior author and the I.H. Kempner professor at the department of biochemistry and molecular biology. “Besides quickly mounting a protective immune response, this live-attenuated vaccine exhibited an excellent safety profile in both mouse and non-human primate models. Taken together, the results suggest that this vaccine merits further development in humans.”

“Having a Zika vaccine that can protect male reproductive systems, pregnant women and their unborn babies would improve public health efforts to avoid birth defects and other effects of the disease in regions where Zika is circulating,” said Pedro Vasconcelos, director of Evandro Chagas Institute in Brazil and co-developer of this vaccine. “It’s important to note that a single-dose vaccine is practically important; vaccines that require booster shots are impractically challenging for people living in developing regions where access to medical facilities may be limited.”

Other authors include UTMB’s Chao Shan, Antonio Muruato, Bruno Nunes, Daniele Medeiros, Xuping Xie, Jannyce Nunes, Alan Barrett, Scott Weaver and Shannan Rossi; Justin Richner, Brett Jagger and Michael Diamond from Washington University School of Medicine; Kaitlyn Morabito, Wing-Pui Kong, Barney Graham and Theodore Pierson from the National Institutes of Health as well as Pedro Vasconcelos from Evandro Chagas Institute, Ministry of Health, Parå State University, Brazil.

The National Institutes of Health, UTMB, The University of Texas System, The Centers for Disease Control and Prevention, the Pan American Health Organization and the Kleberg Foundation, supported this work.

Bennett Jones: International Trade & Investment

Bennett JonesInternational Trade and Investment group is positioned in all aspects of international trade and investment law. Our members have a proven track record of expertise in all of the elements that comprise the regulation of international business, including market access for goods, services, intellectual property and investment. Our practice is also fully integrated with the firm’s extensive cross-border commercial, transactional, tax, banking and dispute settlement services.

The group was established with the objective of becoming best-of-class in Canada. We have formed our team by selective recruitment of proven leaders in all facets of the discipline at both the partner and associate levels, as well as senior advisors who bring the sound judgment necessary for strategic decision-making in the international business and regulatory arena.

Our experience spans domestic trade and investment laws, international rules and treaties, and international dispute settlement in trade and investment matters. Our depth allows us to offer the most comprehensive range of legal services in Canada in relation to international trade and investment regulation. Whether clients require advice on technical border issues or high-level trade policy, treaty negotiation or international relations matters, we are able to draw on our members’ unparalleled expertise in international business regulation to provide timely, practical and informed advice.

Our group includes several partners who are among the most highly-ranked and regarded international trade and investment, customs and commodity tax lawyers in Canada, a former Minister of Public Security (with responsibility for the Canada Border Services Agency), a former ambassador to the United States who was also one of the architects of the Canada-U.S. Free Trade Agreement, and a former Senior Advisor to the Prime Minister of Canada who was intimately involved in every major international initiative, trade negotiation or dispute involving Canada for more than a decade.

We provide advice and represent on matters involving:

*** Customs and Border Administration
*** Commodity Taxes
*** Trade Remedies
*** Trade Agreement, Policy and Negotiations
*** Investment Treaties and Disputes
*** Import and Export Controls
*** Product Regulation and Standards
*** Foreign Corrupt Practices
*** Extraterritorial Measures and Claw-back Statutes
*** Government Procurement and Bid Challenges
*** International Trade and Energy

Select Experience

*** Nordion Inc. in connection with the due diligence aspects of its US$826M acquisition by Sterigenics relating to an investigation by Canadian and US regulatory authorities. Sterigenics is a portfolio company of GTCR LLC, a leading Chicago-based private equity firm.
*** Lone Pine Resources Canada Ltd. and Lone Pine Resources Inc., in connection with a $400-million cross-border recapitalization and restructuring transaction pursuant to a plan of compromise and arrangement under the Companies' Creditors Arrangement Act (Canada) and ancillary proceedings under Chapter 15 of the United States Bankruptcy Code.
*** Sinopec Group in connection with its $2.9 billion acquisition of Daylight Energy Ltd.



Recent Recognitions
*** 2015, Chambers Global: The World's Leading Lawyers for Business
Bennett Jones, ranked, Band 1, International Trade/WTO
Market-leading international practice, acclaimed for the breadth of its expertise in trade law. Areas of service include export controls, anti-corruption, customs administration, WTO agreements and related litigation. The firm is active across a variety of sectors, such as oil and gas, manufacturing and IT. Draws on the strength of its Washington, DC, Beijing, Dubai and Doha offices in addition to its Toronto, Calgary and Vancouver teams. "Bennett Jones has the strongest team in the trade community.""They are committed to trade work in a significant way."

*** 2015, Chambers Global: The World's Leading Lawyers for Business
Darrel H. Pearson, ranked Band 1, International Trade/WTO
Darrel Pearson leads the team alongside Milos Barutciski, and wins praise for his long-standing and extensive experience of customs and trade remedies. In highlights, he advised Bunzl Distribution on trade verification work.

*** 2015, Chambers Global: The World's Leading Lawyers for Business
Milos Barutciski, ranked Band 1, International Trade/WTO
Department co-head Milos Barutciski is dubbed "a fine lawyer - one of the best in the field," by market sources. He is well known for his specialisation in business corruption, and operates a well-respected practice which spans both trade and competition law.

Recent Publications
*** Looking Forward: Canadian Class Actions in 2015
*** Canadian Importers May Now Seek Import Duty Refunds
*** Managing Corruption Risk in the Resource Sector

News & Events
*** Internal Controls Calgary 2015
*** Professionalism Series: China's New Normal: Implications for Canada-China Business
*** Bennett Jones Anti-Corruption Compliance Luncheon Series